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#1
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glycogen/protein replenishment (was lifting and sleeping )
This may be mutating this thread a bit, but I saw this
posted on another newsgroup shortly after I posted something mentioning the role of carbohydrates and protein in recorvery (e.g., after-workout recovery drinks). It also refers to the mechanism behind the post exercise glycogen replacement "window" that I mentioned previously. This is from the medical/dietary consultant for the company that makes Hammer Gel and other products (so it's probably worth more than my advice). Just thought it was interesting... Chris Date: Wed, 25 Aug 2004 18:10:06 -0000 From: "Dr. Bill Misner Ph.D." Subject: From SE to Recoverite Protein:Carb Post-Workout Research supports the concept for utilizing 4 parts carbohydrate to 1 part protein during the 120-minute window-of-opportunity in order to exogenously impact lean muscle mass growth and glycogen restorage. Shortly after Ivy and Burke and several others specified results with a 4:1 ratio, a patented product was then marketed. Another research paper using elderly subjects in a strength exercise (weights) found conclusively that when these subjects lifted weights 3 days per week and consumed 1 part carbohydrate to 1 part protein, they positively achieved lean muscle mass growth gains. This later study skews the conclusion of the former calling for the question of what ratio protein to carbohydrate best supports lean muscle mass growth and glycogen restorage post-depletion workout. In other words, research is inconclusively leaning toward the 4:1 ratio, but has not excluded the 3:1 or 5:1 ratio's due to not having studied them as much as the patented 4:1 ratio. This leaves me with the opinion that as far as conclusive research data go, the jury is still out waiting for more papers to be published on other ratio values. An endurance exercise session lasting more than 3 hours depletes muscle glycogen and likely cannibolizes around 50-60 grams of lean muscle proteins, and probably around 500-600 grams glycogen which should be replaced. The total dietary replacement ratio then is at least 10:1 Carbs:Pro. Since the glycogen synthase enzyme released during glycogen depletion has a short half life effective for 90-120 minutes, but most effectively available at 30 minutes post exercise, it behoves us (according to Colgan, Costill, Noakes, Hawley, Ivy etc) to drive replacement proteins on the insulin-glycogen synthase train for effective maximal replacement. If you try to replace all the glycogen in one or two meals spaced an hour appart with all the protein, too much carbohydrate in one meal will produce excess adipose fatty acid storage. Cutting the carbs down to small dose will produce the insulin and provide maximum storage rate for the protein fraction delivery into the muscle cell for the lean muscle mass rebuilding process. Replacing all of the 70-90 minutes glycogen stores may actually require a 3-day taper with frequent carbohydrate snack/meal intake. The 3:1 carbohydraterotein post-exercise protocol is rational for the endurance athlete, especially if lean muscle mass recovery is the objective. Adding 1 more part carbohydrate raises the carbohydrate component(to 4:1) and may be beneficial for athletes who are free from carbohydrate-induced fat weight. Of the two ratio's, 3:1 or 4:1, the low-carb Recoverite [a Hammer Nutrition product] appears to be favorable for endurance lean muscle gain than the 4:1 higher carb patented formula. Recoverite is formulated for your convenience. Altering the formula in any direction toward more protein or more carbohydrate should be monitored by fat weight gain and lean muscle mass gain accordingly. Since we saw the research that showed positive lean muscle mass growth in older subjects using 1:1 Carb:Pro recovery refueling, our opinion is that the lower carbohydrate version is superior to the higher carbohydrate version. Younger athletes with higher Basal Metabolic Rate, however, can "get by" with consuming higher carbohydrate calories than those of us over age 35...and counting. __________________________________ Do you Yahoo!? New and Improved Yahoo! Mail - 100MB free storage! http://promotions.yahoo.com/new_mail |
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#3
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According to the latest newsletter from Peak Performance
http://www.pponline.co.uk/ , the post-recovery glycogen window of opportunity is a bit of a myth. Evidence suggests that the body is primed to refresh muscle glycogen for several days after glycogen depleting exercise, so there should be no real panic about gorging immediately after a race. I've been experimenting with a cheap home-brew recovery concoction consisting of a package of Carnation Instant Breakfast, soymilk, bananas, blueberries and some good Quebecois yogurt thrown in for "bite" and texture. I think the CHOrotein ratios are in the ballpark and it's cheap. I did a 2 hour run Sunday, a 100k bike ride Monday, and was able to do a 2 hour run the next day without any problems. I don't usually do overdistance workouts on consecutive days but this was an experiment and I was on holidays so I could nap after the workouts... (Steve McGregor) wrote in message . com... It may be mutating a bit, but a pleasant diversion (in my opinion) from Potter's musings. (Friendly rib Jeff) The post is correct, that the literature has not nailed down a specific ratio of CHOrotein for optimal recovery. Part of this is the nature of the exercise bouts used to study this issue, and the definition of recovery. If you are purely concerned with glycogen resynthesis, you probably would want a higher CHOrotein ratio, whereas, if you are concerned with protein recovery (whatever that means) you would want a slightly lower ratio. Another thing that confuses the issue is the type of protein. It may not be protein per se that is important for recovery, but amino acids, specifically essential amino acids. For example, when looking at both protein synthesis, and glycogen synthesis, in different studies Wolfe's group has shown that as little as 4 g of essential amino acids can be as effective as 20 g of whole protein at stimulating glycogen resynthesis and/or protein synthesis. Additionally, consuming one meal immediately following a workout, is not sufficient to sustain recovery. Multiple meals given within a 4 h window are more effective. This is a rather large topic I will leave for now. Thanks for the post. Steve (Chris Cline) wrote in message oo.com... This may be mutating this thread a bit, but I saw this posted on another newsgroup shortly after I posted something mentioning the role of carbohydrates and protein in recorvery (e.g., after-workout recovery drinks). It also refers to the mechanism behind the post exercise glycogen replacement "window" that I mentioned previously. This is from the medical/dietary consultant for the company that makes Hammer Gel and other products (so it's probably worth more than my advice). Just thought it was interesting... Chris Date: Wed, 25 Aug 2004 18:10:06 -0000 From: "Dr. Bill Misner Ph.D." Subject: From SE to Recoverite Protein:Carb Post-Workout Research supports the concept for utilizing 4 parts carbohydrate to 1 part protein during the 120-minute window-of-opportunity in order to exogenously impact lean muscle mass growth and glycogen restorage. Shortly after Ivy and Burke and several others specified results with a 4:1 ratio, a patented product was then marketed. Another research paper using elderly subjects in a strength exercise (weights) found conclusively that when these subjects lifted weights 3 days per week and consumed 1 part carbohydrate to 1 part protein, they positively achieved lean muscle mass growth gains. This later study skews the conclusion of the former calling for the question of what ratio protein to carbohydrate best supports lean muscle mass growth and glycogen restorage post-depletion workout. In other words, research is inconclusively leaning toward the 4:1 ratio, but has not excluded the 3:1 or 5:1 ratio's due to not having studied them as much as the patented 4:1 ratio. This leaves me with the opinion that as far as conclusive research data go, the jury is still out waiting for more papers to be published on other ratio values. An endurance exercise session lasting more than 3 hours depletes muscle glycogen and likely cannibolizes around 50-60 grams of lean muscle proteins, and probably around 500-600 grams glycogen which should be replaced. The total dietary replacement ratio then is at least 10:1 Carbs:Pro. Since the glycogen synthase enzyme released during glycogen depletion has a short half life effective for 90-120 minutes, but most effectively available at 30 minutes post exercise, it behoves us (according to Colgan, Costill, Noakes, Hawley, Ivy etc) to drive replacement proteins on the insulin-glycogen synthase train for effective maximal replacement. If you try to replace all the glycogen in one or two meals spaced an hour appart with all the protein, too much carbohydrate in one meal will produce excess adipose fatty acid storage. Cutting the carbs down to small dose will produce the insulin and provide maximum storage rate for the protein fraction delivery into the muscle cell for the lean muscle mass rebuilding process. Replacing all of the 70-90 minutes glycogen stores may actually require a 3-day taper with frequent carbohydrate snack/meal intake. The 3:1 carbohydraterotein post-exercise protocol is rational for the endurance athlete, especially if lean muscle mass recovery is the objective. Adding 1 more part carbohydrate raises the carbohydrate component(to 4:1) and may be beneficial for athletes who are free from carbohydrate-induced fat weight. Of the two ratio's, 3:1 or 4:1, the low-carb Recoverite [a Hammer Nutrition product] appears to be favorable for endurance lean muscle gain than the 4:1 higher carb patented formula. Recoverite is formulated for your convenience. Altering the formula in any direction toward more protein or more carbohydrate should be monitored by fat weight gain and lean muscle mass gain accordingly. Since we saw the research that showed positive lean muscle mass growth in older subjects using 1:1 Carb:Pro recovery refueling, our opinion is that the lower carbohydrate version is superior to the higher carbohydrate version. Younger athletes with higher Basal Metabolic Rate, however, can "get by" with consuming higher carbohydrate calories than those of us over age 35...and counting. __________________________________ Do you Yahoo!? New and Improved Yahoo! Mail - 100MB free storage! http://promotions.yahoo.com/new_mail |
#4
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(Chris Pella) wrote in message . com...
According to the latest newsletter from Peak Performance http://www.pponline.co.uk/ , the post-recovery glycogen window of opportunity is a bit of a myth. Evidence suggests that the body is primed to refresh muscle glycogen for several days after glycogen depleting exercise, so there should be no real panic about gorging immediately after a race. Umm... no offense to peak performance, but I'm not sure what evidence they are using to support the statement that the glycogen window is a myth. To me, and I'm no Dave Costill, but the wealth of the preponderance of the majority of the..... evidence argues for the glycogen window being relatively short. Now it is likley true that your body, and more importantly muscles, are primed to assimilate amino acids and glucose and store them as proteins and glycogen for several days after glycogen depletion. In fact, I don't dispute that. It's just that there is incontravertible (sp?) evidence that it is primed more during, and immediately following exercise for anywhere from 15 min to 2 hours than days later. It/they are still primed more for up to four hours than days later. Regardless, if the "primed" state was consistent over the course of days, if I wanted to recover sooner for the next workout, I would want to get that recovery started as soon as possible, as opposed to waiting. I've been experimenting with a cheap home-brew recovery concoction consisting of a package of Carnation Instant Breakfast, soymilk, bananas, blueberries and some good Quebecois yogurt thrown in for "bite" and texture. I think the CHOrotein ratios are in the ballpark and it's cheap. I did a 2 hour run Sunday, a 100k bike ride Monday, and was able to do a 2 hour run the next day without any problems. I don't usually do overdistance workouts on consecutive days but this was an experiment and I was on holidays so I could nap after the workouts... With regard to your concoction, back in the day, I used to drink Instant Breakfast as a supplement. I can't recall what the protein content of it is, probably pretty low. I've already stated my take on soy protein for recovery. That's not to say that I am anti-soy, it's just that it is not a good protein source for recovery. There are lots of good things in soy that would be of benefit to overall health, but they could ingested some other time. Steve __________________________________ Do you Yahoo!? New and Improved Yahoo! Mail - 100MB free storage! http://promotions.yahoo.com/new_mail |
#5
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(Steve McGregor) wrote in message . com...
(Chris Pella) wrote in message . com... According to the latest newsletter from Peak Performance http://www.pponline.co.uk/ , the post-recovery glycogen window of opportunity is a bit of a myth. Evidence suggests that the body is primed to refresh muscle glycogen for several days after glycogen depleting exercise, so there should be no real panic about gorging immediately after a race. Umm... no offense to peak performance, but I'm not sure what evidence they are using to support the statement that the glycogen window is a myth. To me, and I'm no Dave Costill, but the wealth of the preponderance of the majority of the..... evidence argues for the glycogen window being relatively short. Now it is likley true that your body, and more importantly muscles, are primed to assimilate amino acids and glucose and store them as proteins and glycogen for several days after glycogen depletion. In fact, I don't dispute that. It's just that there is incontravertible (sp?) evidence that it is primed more during, and immediately following exercise for anywhere from 15 min to 2 hours than days later. It/they are still primed more for up to four hours than days later. Regardless, if the "primed" state was consistent over the course of days, if I wanted to recover sooner for the next workout, I would want to get that recovery started as soon as possible, as opposed to waiting. I probably overstated the case by calling it a myth. The conclusion they made was that "the appropriate time for post-exercise feeding will depend largely on the time available before a subsequent bout." In the distant past I did do a degree in genetics, so I always check to see that the references are at least credible. If you want scientific references, the findings are mostly based on the work of Dr. John Holloszy. Here is a medline snippet from his paper: Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise. Garcia-Roves PM, Han DH, Song Z, Jones TE, Hucker KA, Holloszy JO. Department of Internal Medicine, Washington University School of Medicine, 4566 Scott Avenue, St. Louis, MO 63110, USA. Exercise induces an increase in GLUT4 in skeletal muscle with a proportional increase in glucose transport capacity. This adaptation results in enhanced glycogen accumulation, i.e., "supercompensation," in response to carbohydrate feeding after glycogen-depleting exercise. The increase in GLUT4 reverses within 40 h after exercise in carbohydrate-fed rats. The purpose of this study was to determine whether prevention of skeletal muscle glycogen supercompensation after exercise results in maintenance of the increases in GLUT4 and the capacity for glycogen supercompensation. Rats were exercised by means of three daily bouts of swimming. GLUT4 mRNA was increased approximately 3-fold and GLUT4 protein was increased approximately 2-fold 18 h in epitrochlearis muscle after exercise. These increases in GLUT4 mRNA and protein reversed completely within 42 h after exercise in rats fed a high-carbohydrate diet. In contrast, the increases in GLUT4 protein, insulin-stimulated glucose transport, and increased capacity for glycogen supercompensation persisted unchanged for 66 h in rats fed a carbohydrate-free diet that prevented glycogen supercompensation after exercise. GLUT4 mRNA was still elevated at 42 h but had returned to baseline by 66 h after exercise in rats fed the carbohydrate-free diet. Glycogen-depleted rats fed carbohydrate 66 h after exercise underwent muscle glycogen supercompensation with concomitant reversal of the increase in GLUT4. These findings provide evidence that prevention of glycogen supercompensation after exercise results in persistence of exercise-induced increases in GLUT4 protein and enhanced capacity for glycogen supercompensation I've been experimenting with a cheap home-brew recovery concoction consisting of a package of Carnation Instant Breakfast, soymilk, bananas, blueberries and some good Quebecois yogurt thrown in for "bite" and texture. I think the CHOrotein ratios are in the ballpark and it's cheap. I did a 2 hour run Sunday, a 100k bike ride Monday, and was able to do a 2 hour run the next day without any problems. I don't usually do overdistance workouts on consecutive days but this was an experiment and I was on holidays so I could nap after the workouts... With regard to your concoction, back in the day, I used to drink Instant Breakfast as a supplement. I can't recall what the protein content of it is, probably pretty low. I've already stated my take on soy protein for recovery. That's not to say that I am anti-soy, it's just that it is not a good protein source for recovery. There are lots of good things in soy that would be of benefit to overall health, but they could ingested some other time. I'm just looking for something inexpensive that I can whip up with readily available materials. If there is something more optimal that is readily available without paying an arm and a leg... I'm all ears. We have soy milk in the fridge because my wife can't tolerate milk, that's all. I have no axe to grind for soy. Looking at the nutritional blurb for Instant Breakfast, it says the CHO/protein ratio is 28g/7g. My understanding is that 4:1 is what the commercial recovery drinks are using. Steve __________________________________ Do you Yahoo!? New and Improved Yahoo! Mail - 100MB free storage! http://promotions.yahoo.com/new_mail |
#6
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I probably overstated the case by calling it a myth. The conclusion
they made was that "the appropriate time for post-exercise feeding will depend largely on the time available before a subsequent bout." In the distant past I did do a degree in genetics, so I always check to see that the references are at least credible. If you want scientific references, the findings are mostly based on the work of Dr. John Holloszy. Here is a medline snippet from his paper: Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise. Garcia-Roves PM, Han DH, Song Z, Jones TE, Hucker KA, Holloszy JO. Department of Internal Medicine, Washington University School of Medicine, 4566 Scott Avenue, St. Louis, MO 63110, USA. Exercise induces an increase in GLUT4 in skeletal muscle with a proportional increase in glucose transport capacity. This adaptation results in enhanced glycogen accumulation, i.e., "supercompensation," in response to carbohydrate feeding after glycogen-depleting exercise. The increase in GLUT4 reverses within 40 h after exercise in carbohydrate-fed rats. The purpose of this study was to determine whether prevention of skeletal muscle glycogen supercompensation after exercise results in maintenance of the increases in GLUT4 and the capacity for glycogen supercompensation. Rats were exercised by means of three daily bouts of swimming. GLUT4 mRNA was increased approximately 3-fold and GLUT4 protein was increased approximately 2-fold 18 h in epitrochlearis muscle after exercise. These increases in GLUT4 mRNA and protein reversed completely within 42 h after exercise in rats fed a high-carbohydrate diet. In contrast, the increases in GLUT4 protein, insulin-stimulated glucose transport, and increased capacity for glycogen supercompensation persisted unchanged for 66 h in rats fed a carbohydrate-free diet that prevented glycogen supercompensation after exercise. GLUT4 mRNA was still elevated at 42 h but had returned to baseline by 66 h after exercise in rats fed the carbohydrate-free diet. Glycogen-depleted rats fed carbohydrate 66 h after exercise underwent muscle glycogen supercompensation with concomitant reversal of the increase in GLUT4. These findings provide evidence that prevention of glycogen supercompensation after exercise results in persistence of exercise-induced increases in GLUT4 protein and enhanced capacity for glycogen supercompensation Geez, I don't know about that Holloszy guy. Kidding of course. If it relates to exercise metabolism, he is the man. Specifically with regard to that paper there are a couple of caveats. First, rat metabolism is different than human, so, results of rat studies don't necessarily translate to humans, although these might. Second, GLUT4 translocation is not a measure of glucose uptake and incorporation into glycogen, although it is an indicator of the ability of the cell to take up glucose. That being said, this is my take on the paper, not having read the paper, just the abstract. By delaying glycogen repletion, you are maintaining the cells ability to take up glucose and presumably capacity for glycogen supercompensation. This makes sense because GLUT4 translocation is reliant to a certain extent on the energy state of the cell. If you are depleting the muscle of glycogen and not refeeding it, then the energy state of the cell will remain low. This is great for glucose tolerance and insulin sensitivity, but not great for a workout that you want to perform 24 h after the glycogen depleting bout. Further, we know that glycogen depleting exercise, in conjunction with low CHO feeding results in glycogen supercompensation. This is the foundation of the old approach where one performed overdistance exercise and did not eat CHO, then switched to hi CHO diet to supercompensate glycogen repletion before a big event. In practice though, this results in fatigue in the week leading up to the event, when you want to be fresh and sharp. We have since learned that simply eating a greater amount of CHO in the days leading up to the event, and eliminating the overdistance workout, is more effective from a peformance standpoint. So, we always need to balance the animal and basic data with real world performance data. I'll be the first to admit that I really try to fit basic metabolic data into the performance formula though. Thanks for the abstract, I'll have to get the paper. I've been experimenting with a cheap home-brew recovery concoction consisting of a package of Carnation Instant Breakfast, soymilk, bananas, blueberries and some good Quebecois yogurt thrown in for "bite" and texture. I think the CHOrotein ratios are in the ballpark and it's cheap. I did a 2 hour run Sunday, a 100k bike ride Monday, and was able to do a 2 hour run the next day without any problems. I don't usually do overdistance workouts on consecutive days but this was an experiment and I was on holidays so I could nap after the workouts... With regard to your concoction, back in the day, I used to drink Instant Breakfast as a supplement. I can't recall what the protein content of it is, probably pretty low. I've already stated my take on soy protein for recovery. That's not to say that I am anti-soy, it's just that it is not a good protein source for recovery. There are lots of good things in soy that would be of benefit to overall health, but they could ingested some other time. I'm just looking for something inexpensive that I can whip up with readily available materials. If there is something more optimal that is readily available without paying an arm and a leg... I'm all ears. We have soy milk in the fridge because my wife can't tolerate milk, that's all. I have no axe to grind for soy. Looking at the nutritional blurb for Instant Breakfast, it says the CHO/protein ratio is 28g/7g. My understanding is that 4:1 is what the commercial recovery drinks are using. We touched on this a couple of posts ago, but there is no firmly established optimal ratio. It depends on the caloric requirements of repletion balanced with the amount of protein necessary to enhance recovery. Using the essential amino acid approach, the ratio would be much greater than 4:1, but when I use whole protein, my ratio is about 3:1. The 4:1 ratio has been proposed, and studies funded to a great extent, by companies selling those products . Steve __________________________________ Do you Yahoo!? New and Improved Yahoo! Mail - 100MB free storage! http://promotions.yahoo.com/new_mail |
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